Uncaria Tomentosa Extract

What is Uncaria Tomentosa Extract?

We tested the hydroalcoholic extract of uncaria tomentosa extract stem bark’s in vitro antiviral activity against SARS-CoV-2. The antiviral action of U. tomentosa against SARS-CoV-2 in vitro was surveyed in Vero E6 cells utilizing cytopathic impact (CPE) and plaque decrease measure.

By using a plaque reduction assay on Vero E6 cells, uncaria tree extract inhibited SARS-CoV-2 by 92.7% at 25.0 g/mL () after 48 hours of treatment. U. tomentosa also reduced the CPE caused by SARS-CoV-2 on Vero E6 cells by 98.6% () and 92.7% () at 25 g/mL and 12.5 g/mL, respectively. The EC50 determined for the U. tomentosa remove by plaque decrease examine was 6.6 μg/mL (4.89-8.85 μg/mL) for a selectivity file of 4.1.

Basic Information:

Uncaria Tomentosa Extract Benefits:

1. Sedative effect: uncaria tree extract decoction 0.1 g/kg intraperitoneally injected into mice can produce obvious sedative effect, but no hypnotic effect. Increasing the dose by 25 times does not strengthen the hypnotic and anesthetic effects of pentobarbital. 50 to 100 times can not make the righting reflex disappear, nor cause movement disorders. Uncaria decoction can reduce the excitability of rat cerebral cortex, which is manifested in prolonging or destroying positive conditioned reflexes in some rats, but has no significant effect on differentiation inhibition and unconditioned reflexes.

2. Anti-arrhythmic effect: the total alkaloids of Uncaria give rats iv, aconitine (the dose of the total alkaloids of Uncaria is 15mg/kg), calcium chloride (the dose of the total alkaloids of Uncaria is 10mg/kg), barium chloride (The dose of total alkaloids of rhynchifera is 15mg/kg) has an antagonistic effect on the three kinds of arrhythmias induced. It also has obvious preventive effect on aconitine-induced arrhythmia and calcium chloride-induced ventricular fibrillation. After administration, the arrhythmia induced by barium chloride became uniform, but the P wave disappeared, the S wave deepened, the QRS wave widened, and the PR interval was prolonged. These ECG changes show that the total alkaloids of uncaria tomentosa extract can not only inhibit the ectopic pacemaker, slow down the atrioventricular and indoor conduction, but also inhibit the sinoatrial node.

3. Antihypertensive effect: uncaria tree extract stems, branches, leaves and old branches and other decoctions and ethanol extracts have the effect of lowering blood pressure in anesthetized rabbits. The effect may be to inhibit the vasomotor center, thereby causing peripheral vasodilation, reducing peripheral resistance and reducing blood pressure. Produced, but it is also believed that its antihypertensive effect has obvious cholinergic properties, and its full antihypertensive depends on the integrity of vagus nerve function, and has a synergistic effect with acetylcholine. It is not durable for frying. If it is boiled for more than 20 minutes, the active ingredients for lowering blood pressure will be destroyed, so it should be fried later.

4. Effect on smooth muscle: about 17mg/ml of uncaria tomentosa extract decoction can temporarily reduce the tension of the isolated ileal muscle, and at the same time significantly increase the contraction range; it has anti-histamine effect, but has no anti-nicotine and serotonin effect. Rhynchophylline can inhibit isolated rabbit intestine and excite isolated rat uterus.

5. Other effects: For the guinea pigs with histamine-induced asthma, the anti-asthma rates were 61.5% and 60% (P<0.01) with 10 mg/kgip and 40 mg/kgpo of total alkaloids. The anti-asthma rate of rhynchus total alkaloids increased with the increase of the dosage. For experimental epilepsy in guinea pigs, treatment with Uncaria for 3 to 8 days can prevent the occurrence of epileptic reactions.

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