Toosendanin

What is Toosendanin?

Toosendanin (TSN) is a triterpenoid extracted from Melia toosendan Sieb et Zucc, which was used as a digestive tract-parasiticide and agricultural insecticide in ancient China. TSN was demonstrated to be a selective presynaptic blocker and an effective antibotulismic agent. By interfering with neurotransmitter release through an initial facilitation followed by a subsequent depression, TSN eventually blocks synaptic transmission at both the neuro-muscular junction and central synapses. Despite sharing some similar actions with botulinum neurotoxin (BoNT), TSN has a marked antibotulismic effect in vivo and in vitro.

Studies suggest that the antibotulismic effect of Toosendanin is achieved by preventing BoNT from approaching its enzymatic substrate, the SNARE protein. It is also found that TSN can induce differentiation and apoptosis in several cell lines, and suppress proliferation of various human cancer cells.

Chemical nature

English name: Toosendanin

Plant source: It is the active ingredient proposed from the root bark and bark of Neem.

Molecular formula: C30H38O11 Molecular weight: 574.63

Properties: White crystalline powder, melting point 244～245℃ (decomposition). Optical rotation -13.1° (c=1.75, acetone). It is easily soluble in pyridine, acetone, ethanol, methanol, slightly soluble in chloroform, benzene, and almost insoluble in petroleum ether and water.

Toosendanin Applications:

As a plant-derived insecticide isolated from the bark of Meliaceae and Melia neem, it has stomach toxicity, contact killing and certain antifeedant effects.

1. Prevent and control Lepidopteran pests such as Pieris rapae, Heartworm, Brassica oleracea, Beet Armyworm and other lepidopteran pests.

2. Control aphids

3. Control spider mites

4. Control whitefly on kidney beans

5. Prevention and control of Liriomyza on kidney beans

Uses

After the pests eat and come into contact with melidin, it can block the nerve central conduction, destroy the midgut tissue and various detoxification enzymes and respiratory metabolism, affect digestion and absorption, lose the taste function of food, and prevent the pests from growing and developing. Normal and dead.

The Best Toosendanin Supplier

Green Agri enjoys long term relationships with our clients because we focus on customer service and providing great products. If you are interested in our products, we are flexible with the customization of orders to suit your specific need and our quick lead time on orders guarantees you’ll have great tasting our products on-time.

We also focus on value-added services. We are available for service questions and information to support your business.

Why Choose Toosendanin?

Green Agri specialize in Toosendanin for sale for several years, we supply products with competitive price, and our product is of the highest quality and undergoes strict, independent testing to ensure that it is safe for consumption around the world.

Where to buy Toosendanin?

Just send email to info@greenagribio.com , or submit your requirement in bottom form, we are of service at any time!

Why choose us?

• We offer flexible payment options to make buying our Botanical Pesticide products as easy as possible.
• In the future, we will continue to adhere to the concept of diligence and simplicity, and do a good job in internal management.
• We are dedicated to providing exceptional value to our clients with our affordable Botanical Pesticide products.
• Our vision is that our enterprise has a high reputation in society and our brand enjoys a global reputation.
• Our Botanical Pesticide products are guaranteed to be free from harmful chemicals.
• Our company has been focusing on the production of Toosendanin for many years. We build our brand with heart, and with reliable quality and high-quality service, we will quickly rank among the first-line brands and will enter the international market after success. Now our products are exported to many overseas regions.
• Our factory has stringent quality control measures in place to ensure that our Botanical Pesticide products are of the highest quality.
• We continue to enhance market competitiveness and comprehensive innovation efficiency, and build an enterprise with regional competitiveness and influence.
• Our Botanical Pesticide products are highly effective at eliminating unwanted pests.
• We treat people with sincerity, win the market with ‘excellent quality, advanced technology, and high-quality service’ and strive to become a Toosendanin leader in the sustainable development of the industry.

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